Synbiological systems for complex natural products biosynthesis
نویسندگان
چکیده
منابع مشابه
Synbiological systems for complex natural products biosynthesis
Natural products (NPs) continue to play a pivotal role in drug discovery programs. The rapid development of synthetic biology has conferred the strategies of NPs production. Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways. However, there is still a challenge for integrating a h...
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Actinomycetes populate soils and aquatic sediments that impose biotic and abiotic challenges for their survival. As a result, actinomycetes metabolism and genomes have evolved to produce an overwhelming diversity of specialized molecules. Polyketides, non-ribosomal peptides, post-translationally modified peptides, lactams, and terpenes are well-known bioactive natural products with enormous ind...
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As a continuation of the first two Thematic Series in the Beilstein Journal of Organic Chemistry on natural products in 2011 and 2013 [1,2], it is my pleasure to present the third issue on this topic. Natural products continue to be an inspiring field of research and an important source of potent biologically active compounds. This was recently highlighted by the fact that last year’s Nobel Pri...
متن کاملNatural products in synthesis and biosynthesis
This article is part of the Thematic Series "Natural products in synthesis and biosynthesis". This is the second Thematic Series in the Beilstein Journal of Organic Chemistry focused on natural products. While the first Thematic Series summarized recent research work on the biosynthesis and function of natural products [1,2], the present Thematic Series deals with synthetic and biosynthetic asp...
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Tens of thousands of terpenoid natural products have been isolated from plants and microbial sources. Higher fungi (Ascomycota and Basidiomycota) are known to produce an array of well-known terpenoid natural products, including mycotoxins, antibiotics, antitumor compounds, and phytohormones. Except for a few well-studied fungal biosynthetic pathways, the majority of genes and biosynthetic pathw...
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ژورنال
عنوان ژورنال: Synthetic and Systems Biotechnology
سال: 2016
ISSN: 2405-805X
DOI: 10.1016/j.synbio.2016.08.002